Description

trans-2-Fluorocyclopropanamine Hydrochloride is a high-purity, organofluorine building block essential for advanced pharmaceutical and agrochemical research. This compound is valued for its unique cyclopropane ring structure functionalized with fluorine and an amine group, enabling the synthesis of novel bioactive molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new active pharmaceutical ingredients (APIs), particularly in CNS and antiviral drug discovery.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the metabolic stability imparted by the fluorine atom.
• Chemical Biology Probe: Serves as a versatile scaffold for creating molecular probes to study enzyme mechanisms and biological pathways.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and asymmetric synthesis.
• Material Science Precursor: Acts as a monomer or functionalization agent for advanced polymers and specialty materials.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Item	Detail
Product Name	trans-2-Fluorocyclopropanamine Hydrochloride
CAS No.	114152-96-4
Molecular Formula	C3H7ClFN
Molecular Weight	111.55 g/mol
Synonyms	(1R,2S)-2-Fluorocyclopropanamine Hydrochloride; (1S,2R)-2-Fluorocyclopropanamine Hydrochloride; trans-2-Fluorocyclopropan-1-amine Hydrochloride; 2-Fluorocyclopropylamine Hydrochloride; (±)-trans-2-Fluorocyclopropanamine Hydrochloride; rac-trans-2-Fluorocyclopropanamine Hydrochloride; 2-Fluoro-1-aminocyclopropane Hydrochloride; 1-Amino-2-fluorocyclopropane Hydrochloride
EINECS	Contact for details

Quality Control

Our trans-2-Fluorocyclopropanamine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation via NMR and MS. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality system supports development and commercial supply, with capabilities for custom synthesis under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.