Description

Rel-(1R,2S)-2-Fluorocyclopropan-1-Amine Hydrochloride is a high-value, chiral fluorinated building block essential for modern synthetic chemistry. This compound matters because its unique cyclopropane ring fused with fluorine and amine functionalities enables the precise construction of complex molecules with enhanced metabolic stability and bioavailability. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including potential CNS drugs and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in neurology and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with improved selectivity and environmental profiles.
• Methodology Development: Serves as a critical substrate in academic and industrial research for developing new asymmetric synthesis and fluorination methodologies.
• Ligand and Catalyst Preparation: Employed in the synthesis of chiral ligands and organocatalysts for enantioselective transformations.
• Peptidomimetics & Bioisosteres: The fluorocyclopropylamine moiety is used to replace peptide bonds or other functional groups to modulate the properties of bioactive peptides.
• Material Science Research: Investigated as a monomer or modifier for creating polymers with specific optical or electronic properties.

Basic Information

Product Name	Rel-(1R,2S)-2-Fluorocyclopropan-1-Amine Hydrochloride
CAS No.	114152-95-3
Molecular Formula	C3H7ClFN
Molecular Weight	111.55 g/mol
Synonyms	(1R,2S)-2-Fluorocyclopropanamine Hydrochloride; rel-(1R,2S)-2-Fluorocyclopropanamine HCl; 2-Fluorocyclopropan-1-amine Hydrochloride (rel-(1R,2S)-); 1-Amino-2-fluorocyclopropane Hydrochloride; (±)-(1R,2S)-2-Fluorocyclopropylamine Hydrochloride; 2-Fluorocyclopropylamine Hydrochloride; 114152-95-3; FCyA-HCl
EINECS	Contact for details

Quality Control

Our Rel-(1R,2S)-2-Fluorocyclopropan-1-Amine Hydrochloride is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. Each lot undergoes comprehensive analytical characterization, including chiral purity verification. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. Due to its hygroscopic nature, the container should be kept in a desiccated environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (rel-(1R,2S))
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.