Description

3-(5-Amino-4-Chloro-2-Fluorophenyl)-1-Methyl-6-(Trifluoromethyl)Pyrimidine-2,4(1H,3H)-Dione is a high-value, multi-functional heterocyclic compound that serves as a critical advanced intermediate in modern synthetic chemistry. Its complex structure, featuring amino, chloro, fluoro, and trifluoromethyl substituents, makes it an essential building block for creating molecules with targeted biological activity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and anti-infective therapeutics.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated pyrimidine-dione core.
• Chemical Synthesis Building Block: Serves as a versatile scaffold for medicinal chemistry and structure-activity relationship (SAR) studies due to its multiple reactive sites.
• Material Science Research: Investigated for the development of specialty chemicals and functional materials that require fluorinated aromatic systems.

Basic Information

Product Name	3-(5-Amino-4-Chloro-2-Fluorophenyl)-1-Methyl-6-(Trifluoromethyl)Pyrimidine-2,4(1H,3H)-Dione
CAS No.	114136-76-4
Molecular Formula	C12H8ClF4N3O2
Molecular Weight	337.66 g/mol
Synonyms	1-Methyl-6-(trifluoromethyl)-3-[5-amino-4-chloro-2-fluorophenyl]pyrimidine-2,4(1H,3H)-dione; 3-(5-Amino-4-chloro-2-fluorophenyl)-1-methyl-6-(trifluoromethyl)-1H-pyrimidine-2,4-dione; 5-Amino-4-chloro-2-fluoro-α,α,α-trifluoro-3-(1-methyl-2,4,6-trioxo-1,2,3,4-tetrahydropyrimidin-5-yl)toluene; CAS 114136-76-4
EINECS	Contact for details

Quality Control

Our production of 3-(5-Amino-4-Chloro-2-Fluorophenyl)-1-Methyl-6-(Trifluoromethyl)Pyrimidine-2,4(1H,3H)-Dione adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a detailed Certificate of Analysis (COA). We support cGMP compliance for advanced intermediates and can provide material for regulatory filing purposes upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.