Description

Fmoc-Gly-Odhbt CAS NO 114119-87-8 is a specialized amino acid derivative, specifically an Fmoc-protected glycine activated with the ODHBt ester group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), offering enhanced coupling efficiency and reduced racemization risk. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the production of peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient incorporation of glycine residues into peptide chains.
• Peptide Drug Intermediate Production: For the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Bioconjugation and Labeling: Used to introduce glycine linkers or tags onto proteins, antibodies, or other biomolecules.
• Combinatorial Chemistry Libraries: A key reagent for generating diverse peptide libraries for drug discovery and screening.
• Academic and Industrial Research: For fundamental studies in peptide chemistry, structure-activity relationships (SAR), and novel therapeutic development.
• Synthesis of Glycine-Containing Peptidomimetics: For creating modified peptide analogs with enhanced stability or biological activity.

Basic Information

Product Name	Fmoc-Gly-Odhbt
CAS No.	114119-87-8
Molecular Formula	C26H22N2O6
Molecular Weight	458.47 g/mol
Synonyms	Fmoc-Glycine ODHBt Ester; N-(9-Fluorenylmethoxycarbonyl)glycine 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl Ester; Fmoc-Gly-ODhbt; Fmoc-Gly-OBt; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl ester; 1,2,3-Benzotriazin-4(3H)-one, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]acetyl]oxy]-3,4-dihydro-
EINECS	Contact for details

Quality Control

Our Fmoc-Gly-Odhbt is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and GMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.