Description

Fmoc-Glu(Obut)-Odhbt CAS NO 114119-86-7 is a specialized, high-purity amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). This compound matters because it provides a protected glutamic acid side chain, enabling the controlled and efficient construction of complex peptides and proteins. It is primarily needed by pharmaceutical R&D teams, biotech companies, and CROs engaged in the development of therapeutic peptides, peptide hormones, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the sequential addition of amino acids, particularly where glutamic acid incorporation with side-chain protection is required.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals, including metabolic regulators and hormone analogs.
• Combinatorial Chemistry Libraries: Serves as a building block for creating diverse peptide libraries for drug discovery and screening.
• Bioconjugation and Protein Engineering: Facilitates the site-specific modification of peptides and proteins for creating targeted biopharmaceuticals.
• Academic and Industrial Research: Essential for biochemical studies involving peptide structure-activity relationships (SAR) and enzyme-substrate interactions.
• GMP Manufacturing of APIs: Suitable for use in the synthesis of peptide active pharmaceutical ingredients (APIs) under controlled conditions.

Basic Information

Product Name	Fmoc-Glu(Obut)-Odhbt
CAS No.	114119-86-7
Molecular Formula	C30H28N4O8
Molecular Weight	572.57 g/mol
Synonyms	Fmoc-Glu(OtBu)-ODhbt; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 1-(1,1-dimethylethyl) ester 2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl) ester; Fmoc-L-glutamic acid 5-tert-butyl ester 1-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl) ester; Fmoc-Glu(OtBu)-O-Dhbt; Fmoc-Glu(OBut)-ODhbt Ester; 3-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid 2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl) ester; Dhbt ester of Fmoc-Glu(OtBu)-OH; O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 5-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Obut)-Odhbt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.