Description

Fmoc-Asp(Obut)-Odhbt CAS NO 114119-84-5 is a specialized, protected amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). Its value lies in providing precise stereochemical control and protecting group orthogonality, which are critical for the efficient and high-yield production of complex peptides. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the controlled, sequential addition of aspartic acid in automated peptide synthesizers.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation: Serves as a linker or modified amino acid for creating peptide-protein or peptide-small molecule conjugates.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover novel bioactive peptide leads.
• Academic & Industrial Research: A fundamental tool for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	Fmoc-Asp(Obut)-Odhbt
CAS No.	114119-84-5
Molecular Formula	C28H26N4O7
Molecular Weight	530.53 g/mol
Synonyms	Fmoc-L-aspartic acid β-tert-butyl ester ODHBt ester; Fmoc-Asp(OtBu)-ODhbt; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 1-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl) 4-tert-butyl ester; Fmoc-Asp(OtBu)-ODhbt Ester; Fmoc-Asp(OC(CH3)3)-Odhbt; O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 4-tert-butyl ester; Fmoc-L-Asp(OtBu)-ODhbt; Fmoc-Asp(O-tert-butyl)-ODhbt
EINECS	Contact for details

Quality Control

Our Fmoc-Asp(Obut)-Odhbt is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.