Description

Boc-Phe(4-Nhac)-Oh is a protected amino acid derivative, specifically N-Boc-4-acetamidophenylalanine, widely used in peptide synthesis. This compound is essential for introducing the unique 4-acetamidophenylalanine residue into peptide chains, enabling the study of protein-protein interactions and the development of novel bioactive molecules. It is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity, reliable intermediates for solid-phase and solution-phase peptide synthesis.

Application

• Peptide Synthesis: A key protected amino acid building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Research: Used in the development and production of active pharmaceutical ingredients (APIs) and investigational new drugs that incorporate modified phenylalanine analogs.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or affinity probes used in biochemical assays and diagnostic research.
• Chemical Biology Studies: Enables the site-specific incorporation of a modified aromatic side chain to study enzyme mechanisms, receptor binding, and protein structure-function relationships.
• Material Science: Potential use in the synthesis of specialized polymers and biomaterials with tailored surface properties or bioactivity.

Basic Information

Product Name	Boc-Phe(4-Nhac)-Oh
CAS No.	114117-42-9
Molecular Formula	C₁₆H₂₂N₂O₅
Molecular Weight	322.36 g/mol
Synonyms	N-Boc-4-acetamidophenylalanine; Boc-4-Acetamido-L-phenylalanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-acetamidophenyl)propanoic acid; Boc-Phe(4-AcNH)-OH; Boc-L-Phe(4-NHAc)-OH; N-α-Boc-N-γ-acetyl-L-diaminophenylalanine; Boc-Tyr(4-NHAc)-OH (common misnomer); Fmoc-Phe(4-NHAc)-OH precursor
EINECS	Contact for details

Quality Control

Our Boc-Phe(4-Nhac)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.