Description

Atrial, Natriuretic Factor (1-28), Ala(8)- is a synthetic peptide analog of the endogenous atrial natriuretic peptide (ANP). This compound is of significant value for cardiovascular and renal research, serving as a potent tool for studying natriuresis, diuresis, and vasodilation mechanisms. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutics for hypertension and heart failure.

Application

• Biomedical Research: A critical reference standard and pharmacological tool for investigating the ANP receptor pathway (NPR-A) and its role in blood pressure regulation.
• Drug Discovery & Development: Used in high-throughput screening assays and in vitro/in vivo studies to identify and validate new drug candidates targeting cardiovascular diseases.
• Biochemical Studies: Employed in structure-activity relationship (SAR) studies to understand the impact of specific amino acid substitutions (like Ala at position 8) on peptide stability and biological activity.
• Diagnostic Development: May serve as a calibrator or component in the development of immunoassays for measuring natriuretic peptides in clinical samples.
• Academic & Clinical Research: Fundamental for exploring the pathophysiology of conditions such as congestive heart failure, renal dysfunction, and electrolyte imbalances.

Basic Information

Product Name	Atrial, Natriuretic Factor (1-28), Ala(8)-
CAS No.	114076-99-2
Molecular Formula	C128H202N44O39S2
Molecular Weight	~3081.5 g/mol
Synonyms	ANP (1-28), Ala8-; Atrial Natriuretic Peptide (1-28), Ala(8)-; Atriopeptin (1-28), Ala8-; hANP (1-28), Ala8-; Cardionatrin (1-28), Ala8-; Auriculin A (1-28), Ala8-; 8-Alanine-ANP (1-28); CAS 114076-99-2
EINECS	Contact for details

Quality Control

Our Atrial, Natriuretic Factor (1-28), Ala(8)- is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for peptide synthesis, and specifications can be tailored to meet specific pharmacopeial or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.