Description

α-Msh, Nle(4)-Phe(7)-(Naps)Trp(9)- is a synthetic peptide analog of α-melanocyte-stimulating hormone (α-MSH), engineered for enhanced stability and biological activity. This compound is a critical research tool for studying melanocortin receptor signaling pathways, particularly the MC1R and MC4R subtypes, due to its potent agonist properties. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic, dermatological, and neurological research.

Application

• Biomedical Research: Fundamental studies on melanocortin receptor (MCR) pharmacology, signal transduction, and downstream cellular effects.
• Drug Discovery & Development: Serving as a reference standard or lead compound in the development of novel therapeutics targeting obesity, metabolic syndrome, and inflammation.
• Dermatological Studies: Investigation of skin pigmentation mechanisms, melanogenesis, and potential applications in photoprotection or vitiligo.
• Neuroscience Research: Exploration of the role of melanocortin pathways in feeding behavior, energy homeostasis, and neuroinflammatory processes.
• In Vitro & In Vivo Assays: Functional characterization of receptor activity in cell-based assays and animal models of disease.
• Biochemical Reagent: Use in competitive binding assays, receptor localization studies, and as a control in high-throughput screening (HTS) platforms.

Basic Information

Product Name	α-Msh, Nle(4)-Phe(7)-(Naps)Trp(9)-
CAS No.	113603-78-4
Molecular Formula	C₈₀H₁₀₃N₂₁O₁₄S
Molecular Weight	1647.9 g/mol
Synonyms	Nle4, D-Phe7-α-MSH; [Nle4, D-Phe7]-α-MSH; Melanotan I; MT-I; α-MSH (4-10), Nle4, D-Phe7-; Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂; N-Acetyl-[Nle4, D-Phe7]-α-melanocyte-stimulating hormone amide; NDP-MSH
EINECS	Contact for details

Quality Control

Our α-Msh, Nle(4)-Phe(7)-(Naps)Trp(9)- is manufactured under strict quality systems suitable for research use. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data on purity, peptide content, and solvent residues. Our quality commitment ensures batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.