Description

Fmoc-Gln(Mbh)-Oh CAS NO 113534-17-1 is a protected amino acid derivative, specifically an Fmoc-protected glutamine side-chain protected with a 4-Methylbenzhydryl (Mbh) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for peptide drug development and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated, sequential construction of peptides.
• Pharmaceutical Research: Used in the development and production of therapeutic peptides and peptidomimetics.
• Combinatorial Chemistry: Serves as a building block for generating diverse peptide libraries for drug discovery screening.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for diagnostic or therapeutic applications.
• Academic & Industrial R&D: Fundamental reagent for studying protein structure, function, and interactions.
• Custom Peptide Synthesis Services: A core raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-Gln(Mbh)-Oh
CAS No.	113534-17-1
Molecular Formula	C33H30N2O6
Molecular Weight	550.60 g/mol
Synonyms	Fmoc-Gln(Mbh)-OH; N-α-Fmoc-N-γ-(4-Methylbenzhydryl)-L-glutamine; Fmoc-L-glutamine(Mbh)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((4-methylphenyl)(phenyl)methoxy)-5-oxopentanoic acid; Fmoc-Glutamine(Mbh)-OH; Nα-Fmoc-Nγ-Mbh-L-glutamine; Fmoc-Gln(Mbh)-OH, peptide synthesis grade
EINECS	Contact for details

Quality Control

Our Fmoc-Gln(Mbh)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -18.0° (c=1, DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.