Description

Boc-L-Pyroglutamic Acid Benzyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex peptide frameworks and other bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide-based drugs, and fine chemical intermediates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of L-pyroglutamic acid into peptide chains, particularly for N-terminal modifications.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, hormone analogs, and other bioactive compounds requiring specific stereochemistry.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse arrays of compounds for high-throughput screening in drug discovery.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) and benzyl ester groups provide orthogonal protection strategies for carboxylic acid and amine functionalities during multi-step syntheses.
• Bioconjugation: Employed in the preparation of labeled peptides or peptide-polymer conjugates for diagnostic and therapeutic applications.
• Academic & Industrial Research: A fundamental reagent for methodological studies in organic chemistry and for the synthesis of non-natural amino acids.

Basic Information

Product Name	Boc-L-Pyroglutamic Acid Benzyl Ester
CAS No.	113400-36-5
Molecular Formula	C₁₇H₂₁NO₅
Molecular Weight	319.35 g/mol
Synonyms	Boc-L-pGlu-OBzl; (S)-5-Oxo-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid benzyl ester; 1-Boc-L-pyroglutamic acid benzyl ester; Benzyl (S)-5-oxo-1-((2-methylpropan-2-yl)oxycarbonyl)pyrrolidine-2-carboxylate; N-Boc-L-pyroglutamic acid benzyl ester; N-(tert-Butoxycarbonyl)-L-pyroglutamic acid benzyl ester; L-Pyroglutamic acid, N-(tert-butoxycarbonyl)-, benzyl ester
EINECS	Contact for details

Quality Control

Our Boc-L-Pyroglutamic Acid Benzyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. A Certificate of Analysis (COA) detailing specific results for assay, impurities, and physical characteristics is provided with each shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.