Description

Domitroban is a potent and selective thromboxane A2 (TP) receptor antagonist, representing a significant class of therapeutic agents targeting platelet aggregation and vasoconstriction pathways. Its primary value lies in its potential for research and development of novel treatments for cardiovascular and thrombotic disorders. This compound is essential for pharmaceutical R&D laboratories, academic research institutions, and companies focused on developing antiplatelet and antithrombotic drugs.

Application

• Pharmaceutical Research & Development: A key intermediate or active pharmaceutical ingredient (API) in the development of novel antiplatelet medications.
• Cardiovascular Disease Studies: Used in preclinical and clinical research to investigate treatments for conditions like atherosclerosis, myocardial infarction, and stroke.
• Thrombosis Research: Employed as a pharmacological tool to study the role of thromboxane A2 in platelet activation and thrombus formation.
• Biochemical Assay Development: Serves as a reference standard or inhibitor in assays designed to measure thromboxane receptor activity or screen for new antagonists.
• Mechanism of Action Studies: Utilized to elucidate signaling pathways involving the TP receptor in various cell types and disease models.

Basic Information

Product Name	Domitroban
CAS No.	112966-96-8
Molecular Formula	C24H28N2O5S
Molecular Weight	456.56 g/mol
Synonyms	Domitroban; S-1452; S1452; (+/-)-Domitroban; 5-[[(1R,2S,3R,4S)-3-[(4-fluorophenyl)sulfonylamino]bicyclo[2.2.1]hept-2-yl]methyl]-2-thiophenecarboxylic acid; 5-({3-[(4-Fluorophenyl)sulfonylamino]bicyclo[2.2.1]hept-2-yl}methyl)thiophene-2-carboxylic acid; Thromboxane A2 receptor antagonist S-1452
EINECS	Contact for details

Quality Control

Our Domitroban is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.