Description

2-Iodo-5-(Trifluoromethyl)Pyrimidine is a high-value halogenated pyrimidine building block, essential for advanced organic synthesis. Its molecular structure, featuring both iodine and a trifluoromethyl group, makes it a critical intermediate for introducing these functional motifs into target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrimidine core.
• Material Science Research: Serves as a precursor for creating functionalized organic materials and liquid crystals, where the trifluoromethyl group modifies electronic properties.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl systems.
• Chemical Biology & Proteomics: Utilized as a tagging or labeling reagent in probe development for studying biological systems.

Basic Information

Product Name	2-Iodo-5-(Trifluoromethyl)Pyrimidine
CAS No.	112930-95-7
Molecular Formula	C5H2F3IN2
Molecular Weight	289.98 g/mol
Synonyms	5-(Trifluoromethyl)-2-iodopyrimidine; 2-Iodo-5-(trifluoromethyl)pyrimidine; Pyrimidine, 2-iodo-5-(trifluoromethyl)-; 2-Iodo-5-trifluoromethylpyrimidine
EINECS	Contact for details

Quality Control

Our 2-Iodo-5-(Trifluoromethyl)Pyrimidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.