Description

Fmoc-Met-Osu CAS NO 112913-64-1 is a high-purity, activated ester derivative of Fmoc-protected methionine, specifically designed for efficient peptide synthesis. This compound is a critical building block for the controlled incorporation of methionine residues under mild conditions, ensuring high coupling yields and minimal racemization. It is essential for researchers and manufacturers in pharmaceutical development, proteomics research, and the production of therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the stepwise, Fmoc-based synthesis of peptide chains, particularly for introducing methionine.
• Solution-Phase Peptide Synthesis: Used in classical solution methods for constructing peptide fragments and small peptides.
• Peptide Library Production: Enables the rapid and automated generation of diverse peptide libraries for drug discovery and screening.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides, proteins, and other biomolecules.
• Research & Development: Serves as a fundamental tool in academic and industrial R&D for studying protein structure-function relationships and developing new bioactive compounds.
• API Intermediate Manufacturing: Acts as a crucial intermediate in the synthesis of complex peptide-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Fmoc-Met-Osu
CAS No.	112913-64-1
Molecular Formula	C24H24N2O6S
Molecular Weight	468.52 g/mol
Synonyms	Fmoc-Methionine N-hydroxysuccinimide ester; N-(9-Fluorenylmethoxycarbonyl)-L-methionine N-succinimidyl ester; Fmoc-L-Met-OSu; Fmoc-Met-ONSu; (9H-Fluoren-9-ylmethoxy)carbonyl-L-methionine 2,5-dioxopyrrolidin-1-yl ester; N-α-Fmoc-L-methionine N-hydroxysuccinimide ester; N-Fmoc-L-methionine succinimidyl ester; Fmoc-Methionine-OSu
EINECS	Contact for details

Quality Control

Our Fmoc-Met-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically exceeding 98.5% (HPLC). Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric purity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Specific Rotation	-20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.