Description

Fmoc-D-Gln-Oh CAS NO 112898-00-7 is a protected amino acid derivative where the glutamine side chain is unprotected, and the α-amino group is safeguarded by a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical chiral building block in solid-phase peptide synthesis (SPPS), enabling the controlled, sequential assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the Fmoc-strategy synthesis of custom peptides and small proteins.
• Pharmaceutical Intermediates: Used in the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Serves as a precursor for introducing glutamine residues into biomolecules for labeling or cross-linking studies.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Research: Used in studying enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Proteomics and Genomics: A reagent for synthesizing peptide probes, antigens, and substrates used in various assays.

Basic Information

Product Name	Fmoc-D-Gln-Oh
CAS No.	112898-00-7
Molecular Formula	C₂₀H₂₀N₂O₅
Molecular Weight	368.38 g/mol
Synonyms	Fmoc-D-glutamine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-glutamine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanediamic acid; Fmoc-D-Glutamine-OH; Nα-Fmoc-D-glutamine; Fmoc-D-Gln-OH; D-Fmoc-glutamine; N-Fmoc-D-glutamic acid 5-amide
EINECS	Contact for details

Quality Control

Our Fmoc-D-Gln-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.