Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-[3-[(Methylamino)Methyl]-1-Pyrrolidinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key synthetic precursor in the production of potent fluoroquinolone antibiotics, valued for its critical role in constructing the core pharmacophore. It is primarily required by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and synthesis of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel fluoroquinolone antibiotic APIs (Active Pharmaceutical Ingredients).
• Antibacterial Drug Research: Used in medicinal chemistry R&D for developing new antibacterial compounds with improved efficacy and spectrum of activity.
• Process Chemistry: Employed in scale-up and optimization of manufacturing routes for established antibiotic drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical production.
• Biochemical Research: Utilized in studies investigating the mechanism of action of topoisomerase inhibitors.
• Custom Synthesis: A starting material for the preparation of structurally related analogs for biological screening and patent work.

Basic Information

Item	Details
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-[3-[(Methylamino)Methyl]-1-Pyrrolidinyl]-4-Oxo-
CAS No.	112811-75-3
Molecular Formula	C22H27FN4O4
Molecular Weight	430.47 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-[(methylamino)methyl]-1-pyrrolidinyl)-4-oxo-3-quinolinecarboxylic acid; Gatifloxacin Intermediate; AM-1155 Intermediate; PD-135432; (RS)-1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylaminomethyl-pyrrolidin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-(3-[(Methylamino)methyl]-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for pharmaceutical applications. Quality is verified through comprehensive analytical testing including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.