Description

1-Cyclopropyl-6,7-Difluoro-1,4-Dihydro-8-Methoxy-4-Oxo-3-Quinolinecarboxylic Acid is a high-purity pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of advanced fluoroquinolone antibiotics, valued for its precise molecular structure. It is primarily required by manufacturers in the active pharmaceutical ingredient (API) and fine chemical sectors for research, development, and production.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Essential for synthesizing advanced antibacterial agents like garenoxacin and other third/fourth-generation quinolones.
• Active Pharmaceutical Ingredient (API) Development: Used in R&D for creating new antibacterial drug candidates with improved efficacy and spectrum.
• Fine Chemical Synthesis: Serves as a versatile scaffold for medicinal chemists to develop novel therapeutic compounds.
• Pharmaceutical Research: Employed in academic and industrial laboratories for studying structure-activity relationships (SAR) of quinolone derivatives.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of antibiotic APIs.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.

Basic Information

Item	Details
Product Name	1-Cyclopropyl-6,7-Difluoro-1,4-Dihydro-8-Methoxy-4-Oxo-3-Quinolinecarboxylic Acid
CAS No.	112811-72-0
Molecular Formula	C14H11F2NO4
Molecular Weight	295.24 g/mol
Synonyms	6,7-Difluoro-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Garenoxacin intermediate; DW-116 intermediate; T-3811 intermediate; 3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-; 1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; BMS-284756 intermediate
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-6,7-Difluoro-1,4-Dihydro-8-Methoxy-4-Oxo-3-Quinolinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider conditions under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.