Description

Ethyl [3-(4-Bromo-2-Fluorobenzyl)-7-Chloro-2,4-Dioxo-1,2,3,4-Tetrahydroquinazolin-1-Yl]Acetate is a high-purity, synthetically valuable quinazolinone derivative, serving as a critical pharmaceutical intermediate in modern drug discovery and development. Its complex heterocyclic structure makes it an essential building block for medicinal chemists targeting specific biological pathways. This compound is primarily required by R&D laboratories and production facilities in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery.
• Agrochemical Development: Serves as an intermediate in the research and production of advanced crop protection agents and herbicides.
• Biochemical Tool Compound: Utilized in biochemical assays and as a probe to study enzyme function and cellular mechanisms.
• Custom Synthesis Building Block: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	Ethyl [3-(4-Bromo-2-Fluorobenzyl)-7-Chloro-2,4-Dioxo-1,2,3,4-Tetrahydroquinazolin-1-Yl]Acetate
CAS No.	112733-28-5
Molecular Formula	C20H17BrClFN3O4
Molecular Weight	497.72 g/mol
Synonyms	1,2,3,4-Tetrahydro-7-chloro-3-[(4-bromo-2-fluorophenyl)methyl]-2,4-dioxo-1-quinazolineacetic acid ethyl ester; Ethyl 2-[3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]acetate; 7-Chloro-3-[(4-bromo-2-fluorobenzyl)]-1-(carbethoxymethyl)-2,4(1H,3H)-quinazolinedione; Quinazolinone derivative 112733-28-5; CAS 112733-28-5
EINECS	Contact for details

Quality Control

Our Ethyl [3-(4-Bromo-2-Fluorobenzyl)-7-Chloro-2,4-Dioxo-1,2,3,4-Tetrahydroquinazolin-1-Yl]Acetate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory requirements. We adhere to cGMP principles where applicable to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.