Description

(D-Leu7)-Leuprolide CAS NO 112710-58-4 is a synthetic peptide analog and a key derivative of the gonadotropin-releasing hormone (GnRH) agonist, Leuprolide. This compound is of significant value in pharmaceutical research and development, particularly for creating novel therapeutic agents with modified pharmacokinetic profiles. It is primarily needed by research institutions, pharmaceutical companies, and biotechnology firms engaged in advanced peptide chemistry, endocrinology research, and the development of targeted hormone therapies.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and intermediate in the synthesis of novel GnRH analogs for therapeutic applications.
• Endocrinology Studies: Used as a biochemical tool to investigate the structure-activity relationships (SAR) of peptide hormones and their receptors.
• Peptide Chemistry: Acts as a building block or a model compound for studying peptide stability, modification, and synthesis techniques.
• Preclinical Development: Employed in the development and validation of analytical methods (e.g., HPLC, MS) for peptide-based drug candidates.
• Academic Research: Utilized in university and institutional labs for fundamental research in reproductive biology and hormone signaling pathways.

Basic Information

Product Name	(D-Leu7)-Leuprolide
CAS No.	112710-58-4
Molecular Formula	C59H84N16O12
Molecular Weight	1209.4 g/mol
Synonyms	D-Leu7-Leuprolide; [D-Leucine7]-Leuprolide; Leuprolide (D-Leu7) analog; 5-Oxo-Pro-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt; Gonadorelin (6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide); GnRH agonist derivative; LHRH agonist analog
EINECS	Contact for details

Quality Control

Our (D-Leu7)-Leuprolide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure the correct stereochemistry. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, related substances, and residual solvents in compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.