Description

Ethyl 3-(4-Bromo-2-Fluorophenyl)-3-Oxopropanoate is a high-purity, versatile β-keto ester building block featuring a halogenated aromatic ring system. This compound is critical for the synthesis of complex molecules, offering a reactive handle for further functionalization via its ketone and ester groups. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides, leveraging the halogenated phenyl moiety for bioactivity.
• Chemical Research: Serves as a versatile precursor in organic synthesis for constructing complex heterocycles, such as pyrazoles and isoxazoles, via condensation reactions.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with unique optical or electronic properties.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke fine chemicals and advanced intermediates for clients.

Basic Information

Product Name	Ethyl 3-(4-Bromo-2-Fluorophenyl)-3-Oxopropanoate
CAS No.	112704-80-0
Molecular Formula	C11H10BrFO3
Molecular Weight	289.10 g/mol
Synonyms	Ethyl 4-Bromo-2-fluorobenzoylacetate; Ethyl (4-Bromo-2-fluorobenzoyl)acetate; 3-Oxobutanoic acid, 3-(4-bromo-2-fluorophenyl)-, ethyl ester; 4-Bromo-2-fluorobenzoylacetic acid ethyl ester; Acetoacetic acid, (4-bromo-2-fluorobenzoyl)-, ethyl ester; Ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropionate; 112704-80-0; Ethyl β-(4-bromo-2-fluorobenzoyl)propionate
EINECS	Contact for details

Quality Control

Our Ethyl 3-(4-Bromo-2-Fluorophenyl)-3-Oxopropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.