Description

(D-Leu6)-Lhrh (1-8) CAS NO 112642-14-5 is a synthetic peptide analog of Gonadotropin-Releasing Hormone (GnRH), featuring a D-amino acid substitution at the sixth position. This structural modification enhances its metabolic stability and receptor binding affinity, making it a critical tool for advanced endocrinology and reproductive biology research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in developing novel therapeutic agents and diagnostic tools for hormone-related conditions.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of novel GnRH-based therapeutics for treating hormone-dependent cancers (e.g., prostate, breast) and reproductive disorders.
• Endocrinology Studies: Used in in vitro and in vivo assays to study the structure-activity relationship (SAR) of GnRH analogs, receptor binding kinetics, and downstream signaling pathways.
• Biochemical Reagent: Employed as a high-purity biochemical reagent for calibrating analytical instruments (HPLC, MS) and validating bioassay methods in quality control laboratories.
• Veterinary Medicine Development: Investigated for applications in animal health, including fertility control and the management of reproductive cycles in livestock and companion animals.
• Diagnostic Kit Manufacturing: Acts as a critical component in the production of immunoassay kits and diagnostic tests designed to measure GnRH or related hormone levels.

Basic Information

Product Name	(D-Leu6)-Lhrh (1-8)
CAS No.	112642-14-5
Molecular Formula	C56H78N16O12
Molecular Weight	1119.3 g/mol
Synonyms	(D-Leu6)-LHRH (1-8); (Des-Gly10, D-Leu6)-LHRH ethylamide (1-8); Gonadorelin (1-8) analog, D-Leu6; D-Leu6-GnRH (1-8); Luteinizing Hormone-Releasing Hormone fragment (1-8) with D-Leucine at position 6; pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-NH2; D-Leu6-LHRH (1-8)EA
EINECS	Contact for details

Quality Control

Every batch of (D-Leu6)-Lhrh (1-8) is manufactured and tested under a strict quality management system. We guarantee high purity and batch-to-batch consistency through comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all test results are available upon request. Our production adheres to cGMP guidelines suitable for research and pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.