Description

(Fmoc-Cys-Osu)2, (Disulfide Bond) is a specialized, high-purity chemical building block featuring a pre-formed disulfide linkage. This compound is critical for the efficient and controlled synthesis of peptides and proteins, particularly in solid-phase peptide synthesis (SPPS) where the introduction of a stable, orthogonal disulfide bond is required. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, protein mimetics, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled introduction of intramolecular or intermolecular disulfide bridges in synthetic peptides.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs where disulfide bonds are crucial for structural stability and biological activity.
• Protein Engineering & Mimetics: Facilitates the creation of stabilized protein fragments, cyclic peptides, and constrained peptide structures for drug discovery.
• Bioconjugation & Linker Chemistry: Serves as a versatile reagent for creating cleavable or stable cross-links between biomolecules or to solid supports.
• Chemical Biology Research: Employed in studies of protein folding, oxidative folding pathways, and structure-activity relationships (SAR).
• Antibody-Drug Conjugate (ADC) Payload Synthesis: Can be utilized in the synthesis of specialized linker-payload constructs for targeted cancer therapies.

Basic Information

Product Name	(Fmoc-Cys-Osu)2, (Disulfide Bond)
CAS No.	112514-60-0
Molecular Formula	C40H32N4O12S2
Molecular Weight	824.82 g/mol
Synonyms	Bis[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-cysteinyl] Disuccinimide; Fmoc-Cys(OSu)-Cys(OSu)-Fmoc Disulfide; Nα-Fmoc-S-succinimidyl-L-cysteine Disulfide; Fmoc-Cysteine(OSu) Disulfide; Fmoc-Cys(OSu) Disulfide; Fmoc-Cysteine N-Hydroxysuccinimide Ester Disulfide; Fmoc-Cys-Osu Dimer; Fmoc-L-Cysteine Succinimidyl Ester Disulfide
EINECS	Contact for details

Quality Control

Our (Fmoc-Cys-Osu)2, (Disulfide Bond) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Store in a cool, dry, well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.