Description

Tandospirone Citrate CAS NO 112457-95-1 is a high-purity pharmaceutical intermediate and active ingredient, specifically the citrate salt of tandospirone. This compound is of significant commercial importance as a key building block in the synthesis of anxiolytic and antidepressant medications. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in neuropharmacology and drug development.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in anxiolytic and antidepressant formulations.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research: Used in preclinical and clinical studies to investigate mechanisms of action related to serotonin (5-HT1A) receptor agonism.
• Process Development: Employed as a critical intermediate in the scale-up and optimization of synthetic routes for finished dosage forms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of generic and proprietary neuropsychiatric drugs.

Basic Information

Product Name	Tandospirone Citrate
CAS No.	112457-95-1
Molecular Formula	C21H29N5O2 • C6H8O7
Molecular Weight	651.66 g/mol
Synonyms	Tandospirone citrate; SM-3997; Sediel; Metanopirone citrate; 3aa,4b,7b,7aa-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione citrate; 4-[4-(Pyrimidin-2-yl)piperazin-1-yl]butyl 8-azaspiro[4.5]decane-7,9-dione citrate
EINECS	Contact for details

Quality Control

Our Tandospirone Citrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency for our global pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.