Description

Fmoc-Tyr(2,6-Dichloro-Bzl)-Oh is a protected tyrosine derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly for complex or therapeutic peptides. It is an essential building block for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel peptide-based drugs and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the sequential assembly of peptide chains on resin supports.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation and Probe Development: The protected phenolic hydroxyl group allows for selective deprotection and subsequent modification, useful for creating fluorescent or affinity-tagged peptides.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: Employed in fundamental studies of protein structure-function relationships and peptide biochemistry.
• Custom Peptide Service Providers: A standard reagent for CROs and CDMOs offering bespoke peptide synthesis services to the biotech and pharmaceutical industries.

Basic Information

Product Name	Fmoc-Tyr(2,6-Dichloro-Bzl)-Oh
CAS No.	112402-12-7
Molecular Formula	C32H25Cl2NO5
Molecular Weight	574.45 g/mol
Synonyms	Fmoc-O-(2,6-Dichlorobenzyl)-L-tyrosine; N-(9-Fluorenylmethoxycarbonyl)-O-(2,6-dichlorobenzyl)-L-tyrosine; Fmoc-Tyr(2,6-Cl2-Bzl)-OH; Fmoc-L-Tyrosine(O-2,6-dichlorobenzyl); (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[4-[(2,6-dichlorophenyl)methoxy]phenyl]propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr(2,6-Dichloro-Bzl)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% L-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.