Description

Phenylalanyl-Glycyl-Histidyl-Statyl-Alanyl-Phenylalanine Methyl Ester CAS NO 112317-45-0 is a synthetic peptide derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard in the synthesis and study of more complex bioactive peptides and peptidomimetics. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in drug discovery, metabolic studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase or solution-phase synthesis of complex peptide-based drug candidates.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies, receptor binding assays, and metabolic pathway investigations.
• Drug Discovery: Serves as a core structure for the development and optimization of novel therapeutics targeting specific enzymes or receptors.
• Protease Inhibitor Studies: Particularly relevant for research into statine-containing peptides, which are known as potent inhibitors of aspartic proteases like renin and HIV protease.
• Academic Research: Employed in university and institutional labs for studying peptide chemistry, stability, and structure-activity relationships (SAR).
• Quality Control Standard: Acts as a high-purity analytical standard for method development and validation in QC laboratories within the pharmaceutical sector.

Basic Information

Item	Details
Product Name	Phenylalanyl-Glycyl-Histidyl-Statyl-Alanyl-Phenylalanine Methyl Ester
CAS No.	112317-45-0
Molecular Formula	C41H52N10O8
Molecular Weight	812.93 g/mol
Synonyms	Phe-Gly-His-Sta-Ala-Phe-OMe; H-Phe-Gly-His-Sta-Ala-Phe-OMe; (3S,4S)-4-Amino-3-hydroxy-6-methylheptanoyl-containing peptide; Statine-containing hexapeptide methyl ester; Aspartic protease inhibitor peptide analog; Renin inhibitor peptide fragment; HIV protease inhibitor intermediate; N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(3S,4S)-4-Amino-3-hydroxy-6-methylheptanoyl]-L-alanyl]-L-phenylalanyl]methyl]-2-oxoethyl]-L-histidyl]glycyl]-L-phenylalanine methyl ester
EINECS	Contact for details

Quality Control

Our Phenylalanyl-Glycyl-Histidyl-Statyl-Alanyl-Phenylalanine Methyl Ester is produced under strict quality management systems suitable for research and development applications. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, MS, and NMR to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.