Description

4-Bromo-2,3-Difluoroaniline is a halogenated aniline derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents on the aromatic ring, makes it a valuable precursor for creating complex molecules with tailored properties. This intermediate is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic diamines and other compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific characteristics such as flame retardancy, chemical resistance, or altered thermal properties.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of complex, halogenated dyes and pigments for high-performance applications.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing biaryl and other complex structures in medicinal chemistry.

Basic Information

Product Name	4-Bromo-2,3-Difluoroaniline
CAS No.	112279-72-8
Molecular Formula	C6H4BrF2N
Molecular Weight	208.00 g/mol
Synonyms	2,3-Difluoro-4-bromoaniline; 4-Bromo-2,3-difluorobenzenamine; 1-Amino-4-bromo-2,3-difluorobenzene; Benzenamine, 4-bromo-2,3-difluoro-; 4-Bromo-2,3-difluoro-phenylamine; 4-Br-2,3-F2-C6H2-NH2
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3-Difluoroaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-proof secondary packaging.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.