Description

3-Bromo-2,5-Difluorobenzaldehyde is a versatile and highly functionalized aromatic aldehyde building block. Its molecular structure, featuring both bromine and fluorine substituents adjacent to the reactive formyl group, makes it a critical intermediate for constructing complex molecules in advanced research and development. This compound is primarily sought after by pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, ligand synthesis, and the development of specialty polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the halogenated aromatic core contributes to biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing sophisticated ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science & OLEDs: Employed in the creation of fluorinated organic semiconductors, liquid crystals, and electron-transport materials for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl structures.
• Fine Chemical Synthesis: Utilized as a building block for dyes, pigments, and other high-value specialty chemicals requiring a difluorobenzene scaffold.

Basic Information

Item	Detail
Product Name	3-Bromo-2,5-Difluorobenzaldehyde
CAS No.	112279-64-8
Molecular Formula	C7H3BrF2O
Molecular Weight	221.00 g/mol
Synonyms	2,5-Difluoro-3-bromobenzaldehyde; 3-Bromo-2,5-difluorobenzenecarboxaldehyde; Benzaldehyde, 3-bromo-2,5-difluoro-; 3-Br-2,5-F2-C6H2CHO
EINECS	Contact for details

Quality Control

Our 3-Bromo-2,5-Difluorobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve purity and prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.