Description

(4,4'-Dehydrophenylalanine)Gramicidin S is a synthetic cyclic decapeptide analog of the natural antibiotic Gramicidin S, engineered with a modified phenylalanine residue. This structural modification is designed to enhance its biological activity profile and stability for advanced research applications. It serves as a critical tool compound for pharmaceutical R&D, particularly in the study of antimicrobial mechanisms, membrane interactions, and the development of novel peptide-based therapeutics.

Application

• Antimicrobial Research: Used as a reference standard and active agent in studies targeting Gram-positive bacteria and fungi.
• Membrane Biophysics: Investigated for its ionophoric properties and interactions with lipid bilayers to understand pore formation and membrane disruption.
• Pharmaceutical Development: Serves as a lead compound or structural template for designing new peptide antibiotics with improved efficacy and reduced toxicity.
• Biochemical Assays: Employed in high-throughput screening (HTS) platforms to identify synergistic compounds or resistance mechanisms.
• Academic & Institutional Research: A key reagent for universities and research institutes focusing on peptide chemistry, microbiology, and medicinal chemistry.

Basic Information

Product Name	(4,4'-Dehydrophenylalanine)Gramicidin S
CAS No.	112209-92-4
Molecular Formula	C60H90N12O10
Molecular Weight	~1139.4 g/mol
Synonyms	Gramicidin S, 4,4'-Dehydrophenylalanine analog; Cyclo(-Val-Orn-Leu-D-Phe-Pro-)2 analog; Dehydro-Phe Gramicidin S; Synthetic Gramicidin S derivative; Antibiotic peptide analog; [4,4'-Dehydro-Phe] Gramicidin S; Gramicidin S (4,4'-dehydrophenylalanine form); GS analog
EINECS	Contact for details

Quality Control

Our (4,4'-Dehydrophenylalanine)Gramicidin S is produced under strict quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency suitable for research applications. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, MS confirmation, and other relevant analytical data is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, ethanol; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.