Description

Pam3Cys-Ser-(Lys)4 Tfa is a synthetic lipopeptide derivative of the bacterial lipoprotein Pam3Cys, widely recognized as a potent toll-like receptor 2 (TLR2) agonist. This compound is crucial for its ability to robustly stimulate innate immune responses, making it an essential tool in immunological research and vaccine adjuvant development. It is primarily utilized by pharmaceutical R&D teams, immunologists, and biotech companies focused on novel vaccine formulations and immunomodulatory therapies.

Application

• Vaccine Adjuvant Research: As a potent TLR2 agonist, it is extensively used in preclinical studies to enhance the immunogenicity of subunit and peptide-based vaccines.
• Immunology Studies: Serves as a critical reagent for activating antigen-presenting cells like dendritic cells and macrophages to study innate immune signaling pathways.
• Drug Delivery Systems: Incorporated into liposomal or nanoparticle formulations to target immune cells and improve therapeutic delivery.
• Cancer Immunotherapy: Investigated as a component in therapeutic cancer vaccines to boost anti-tumor immune responses.
• Antiviral & Antibacterial Research: Used in studies aiming to develop novel treatments by modulating host defense mechanisms against pathogens.
• Cell Culture & In Vitro Assays: Applied in cell-based assays to induce cytokine production and study immune cell activation.

Basic Information

Product Name	Pam3Cys-Ser-(Lys)4 Tfa
CAS No.	112208-01-2
Molecular Formula	C84H147N19O19S
Molecular Weight	1699.3 g/mol
Synonyms	Pam3Cys-SK4; N-Palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine trifluoroacetate; S-[2,3-Bis(palmitoyloxy)propyl]-N-palmitoylcysteinylseryllysyllysyllysyllysine TFA; TLR2 Agonist Pam3CSK4 TFA; Lipopeptide TLR2 Ligand; N-Palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-(R)-cysteinyl-seryl-(lysyl)4 trifluoroacetate
EINECS	Contact for details

Quality Control

Our Pam3Cys-Ser-(Lys)4 Tfa is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP-like guidelines for peptide synthesis to meet the stringent requirements of pharmaceutical and biological research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.