Description

Vasoactive Intestinal Peptide (1-12) is a specific, biologically active fragment of the full-length vasoactive intestinal peptide (VIP). This peptide fragment is a crucial research tool for studying the structure-activity relationships and receptor binding domains of VIP. It is primarily utilized in advanced biochemical research and pharmaceutical development, particularly in neuroscience, endocrinology, and immunology, where understanding VIP's mechanisms is essential.

Application

• Biochemical Research: Used as a reference standard and active fragment in studies investigating the physiological functions and signaling pathways of Vasoactive Intestinal Peptide.
• Neuroscience Studies: Applied in research on neuroprotection, cerebral blood flow regulation, and the role of VIP in the central and peripheral nervous systems.
• Drug Discovery & Development: Serves as a key intermediate or pharmacophore model for designing novel therapeutic agents targeting VIP receptors for conditions like inflammatory diseases and neurodegeneration.
• Immunology Research: Employed to study the immunomodulatory effects of VIP fragments on cytokine production and immune cell function.
• Receptor Binding Assays: Utilized in competitive binding experiments to characterize and map VIP receptor subtypes (VPAC1, VPAC2).
• Academic & Institutional Laboratories: A fundamental reagent for universities and research institutes conducting peptide hormone research.

Basic Information

Product Name	Vasoactive Intestinal Peptide (1-12)
CAS No.	112160-96-0
Molecular Formula	C66H103N19O19
Molecular Weight	1442.65 g/mol
Synonyms	VIP (1-12); VIP Fragment 1-12; Vasoactive Intestinal Polypeptide (1-12); H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-OH; VIP 1-12 Peptide; Vasoactive Intestinal Peptide 1-12; VIP 1-12 Fragment
EINECS	Contact for details

Quality Control

Our Vasoactive Intestinal Peptide (1-12) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from HPLC, MS, and amino acid analysis. Quality standards are aligned with research-grade requirements, and custom synthesis to specific purity grades (e.g., >95%, >98%) is available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.