Description

Kaliuretic Peptide (Human) CAS NO 112160-83-5 is a synthetic peptide hormone fragment with significant biological activity. This compound is of critical importance for research into renal physiology and cardiovascular regulation, specifically concerning natriuresis and kaliuresis. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutics for hypertension, heart failure, and electrolyte balance disorders.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating the mechanisms of atrial natriuretic peptide (ANP) and its effects on sodium and potassium excretion.
• Pharmacological Studies: Employed in in vitro and in vivo assays to screen for drug candidates targeting natriuretic peptide receptors (NPRs) for cardiovascular and renal diseases.
• Diagnostic Development: Serves as a critical component in the development and calibration of immunoassays and biosensors designed to detect natriuretic peptide levels in biological samples.
• Peptide Chemistry Reference: Acts as a high-purity standard for analytical method development (HPLC, MS) and for quality control in peptide synthesis workflows.
• Cell Signaling Research: Utilized to study intracellular signaling pathways (e.g., cGMP activation) triggered by peptide hormones in renal and vascular tissue models.

Basic Information

Product Name	Kaliuretic Peptide (Human)
CAS No.	112160-83-5
Molecular Formula	C119H190N40O33
Molecular Weight	2685.0 g/mol (approximate)
Synonyms	Atrial Natriuretic Peptide (ANP) (105-126), human; ANP (105-126); hANP (105-126); Kaliuretic Peptide; Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23); Cardionatrin I (105-126); CDD/ANP-22; Auriculin A (105-126).
EINECS	Contact for details

Quality Control

Our Kaliuretic Peptide (Human) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including reversed-phase HPLC for purity assessment and mass spectrometry for identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.