Description

(S)-6-Chloro-9-(1-Phenylethyl)-9H-Purine CAS NO 112089-31-3 is a high-purity chiral purine derivative, a crucial building block in advanced organic synthesis. Its value lies in its role as a key intermediate for the development of novel pharmaceutical compounds, particularly in the research of adenosine receptor modulators and kinase inhibitors. This product is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to create new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of potential drug candidates targeting various disease pathways.
• Adenosine Receptor Research: Used in the development of selective agonists and antagonists for A1, A2A, A2B, and A3 adenosine receptors.
• Kinase Inhibitor Development: Serves as a core scaffold for creating novel compounds that modulate protein kinase activity.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship studies to optimize the potency and selectivity of lead molecules.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: Acts as a reference standard or a starting point for creating labeled analogs used in biological assays.

Basic Information

Product Name	(S)-6-Chloro-9-(1-Phenylethyl)-9H-Purine
CAS No.	112089-31-3
Molecular Formula	C13H11ClN4
Molecular Weight	258.71 g/mol
Synonyms	(S)-6-Chloro-9-(1-phenylethyl)-9H-purine; (S)-6-Chloro-9-(α-methylbenzyl)-9H-purine; 9-[(1S)-1-Phenylethyl]-6-chloro-9H-purine; 6-Chloro-9-[(1S)-1-phenylethyl]purine; (S)-6-Chloro-9-(1-phenylethyl)purine; 112089-31-3; SCHEMBL2188301; ZINC000005098761
EINECS	Contact for details

Quality Control

Our (S)-6-Chloro-9-(1-Phenylethyl)-9H-Purine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and chiral excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.