Description

H-Ala-Ala-Ala-Tyr-OH is a synthetic tetrapeptide sequence composed of three alanine residues followed by a tyrosine. This compound is a crucial building block in peptide research and pharmaceutical development, offering a defined structure for studying enzyme-substrate interactions and protein folding. It is primarily utilized by research institutions and pharmaceutical companies engaged in proteomics, biochemical assay development, and the synthesis of more complex bioactive peptides.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic studies, particularly for proteases like chymotrypsin which cleave after tyrosine residues.
• Pharmaceutical Intermediates: Serves as a key fragment in the solid-phase or solution-phase synthesis of longer therapeutic peptide candidates.
• Proteomics & Mass Spectrometry: Employed as a calibration standard or model compound in mass spectrometry for peptide analysis and method development.
• Structure-Activity Relationship (SAR) Studies: Provides a core scaffold for investigating the impact of specific amino acid sequences on biological activity and stability.
• Academic & Industrial R&D: Fundamental tool in university and corporate laboratories for training and experimental work in peptide chemistry and molecular biology.

Basic Information

Product Name	H-Ala-Ala-Ala-Tyr-OH
CAS No.	112079-60-4
Molecular Formula	C18H25N4O6
Molecular Weight	393.42 g/mol
Synonyms	Ala-Ala-Ala-Tyr-OH; AAAY-OH; H-Ala-Ala-Ala-Tyrosine; L-Alanyl-L-alanyl-L-alanyl-L-tyrosine; Tetrapeptide AAAY; N-(N-(N-L-Alanyl-L-alanyl)-L-alanyl)-L-tyrosine; AAY; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]propanoyl]amino]propanoic acid
EINECS	Contact for details

Quality Control

Our H-Ala-Ala-Ala-Tyr-OH is produced under stringent conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.