Description

Quetiapine CAS NO 111974-69-7 is an atypical antipsychotic pharmaceutical active ingredient, chemically known as 2-(2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy)ethanol. It is a critical compound in the development and production of medications for treating major psychiatric disorders. This active pharmaceutical ingredient (API) is essential for manufacturers in the global pharmaceutical industry, particularly those specializing in central nervous system (CNS) therapeutics.

Application

• Primary Pharmaceutical Ingredient: Used as the key active component in the formulation of quetiapine fumarate tablets and extended-release tablets.
• Schizophrenia Treatment: A core API for medications managing symptoms of schizophrenia, including hallucinations, delusions, and disorganized thinking.
• Bipolar Disorder Management: Essential for producing drugs used in the treatment of acute manic and depressive episodes associated with bipolar I disorder.
• Major Depressive Disorder (MDD) Adjunct Therapy: Used in the manufacture of antidepressants as an adjunctive treatment for MDD.
• Generic Drug Production: Serves as the foundational compound for numerous generic pharmaceutical companies worldwide following patent expirations.
• Clinical Research & Development: Employed in preclinical and clinical studies for investigating new therapeutic applications and formulations.
• Dosage Form Development: Utilized in R&D for developing various oral solid dosage forms, including controlled-release mechanisms.

Basic Information

Product Name	Quetiapine
CAS No.	111974-69-7
Molecular Formula	C21H25N3O2S
Molecular Weight	383.51 g/mol
Synonyms	Quetiapine Base; ICI 204,636; 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol; Seroquel (Brand Name API); 11-Piperazinyldibenzo[b,f][1,4]thiazepine Derivative; Ketipinor; Quetiapinum; Bietiapine; Quetiapin
EINECS	Contact for details

Quality Control

Our Quetiapine is manufactured under strict quality management systems. We provide material that meets or exceeds the standards of major pharmacopoeias, including USP (United States Pharmacopeia) and EP (European Pharmacopoeia). Every batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. Certificates of Analysis (COA) documenting all test results are provided and available upon request to ensure full traceability and regulatory compliance for our pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.