Description

1β-Hydroxytaurodeoxycholic Acid Sodium is a high-purity, conjugated bile acid derivative, specifically the taurine amide of 1β-hydroxydeoxycholic acid. This compound is a critical biochemical reagent and reference standard valued for its defined structure and purity in advanced research and development. It is primarily utilized by pharmaceutical researchers, diagnostic developers, and academic institutions engaged in metabolic studies, hepatobiliary research, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a key reference standard and analytical reagent in the study of bile acid metabolism, transport, and signaling pathways.
• Pharmaceutical Development: Serves as a critical intermediate or reference compound in the R&D of novel therapeutics targeting liver diseases, cholestasis, and metabolic disorders.
• Diagnostic Assays: Employed in the calibration and development of clinical diagnostic kits and LC-MS/MS methods for quantifying bile acid profiles in biological samples.
• Cell Culture & Physiology Studies: Applied in *in vitro* studies to investigate the effects of specific bile acid species on cell membrane integrity, receptor activation, and cellular function.
• Enzymology: Acts as a specific substrate or inhibitor for enzymes involved in bile acid synthesis and conjugation, such as bile acid-CoA:amino acid N-acyltransferase (BAAT).

Basic Information

Product Name	1β-Hydroxytaurodeoxycholic Acid Sodium
CAS No.	111945-04-1
Molecular Formula	C₂₆H₄₄NNaO₇S
Molecular Weight	537.68 g/mol
Synonyms	1β-Hydroxy-TDCA Sodium Salt; Sodium 1β-Hydroxytaurodeoxycholate; Tauro-1β-hydroxydeoxycholic Acid Sodium Salt; 1β-HTDCA Na; N-[(3α,5β,12α)-1β,3α,12-Trihydroxy-24-oxocholan-24-yl]taurine Sodium Salt; 1β-Hydroxy-3α,12α-dihydroxy-5β-cholan-24-oic Acid N-(2-sulfoethyl)amide Sodium Salt
EINECS	Contact for details

Quality Control

Our 1β-Hydroxytaurodeoxycholic Acid Sodium is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.