Description

(D-Arg0,Hyp2,3,D-Phe7)-Bradykinin is a synthetic, modified peptide analog of the endogenous vasoactive peptide bradykinin. This compound is specifically engineered to exhibit enhanced stability and selective biological activity, making it a critical tool for advanced pharmacological research. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for studying cardiovascular systems, inflammatory pathways, and pain mechanisms, as well as for the development of novel therapeutic agents.

Application

• Pharmacological Research: Used as a stable analog to study the bradykinin B1 and B2 receptor signaling pathways and their roles in inflammation, pain, and vascular permeability.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the design of new anti-inflammatory, analgesic, or cardiovascular drugs.
• Biochemical Assays: Employed in in vitro and cell-based assays to investigate peptide-receptor interactions and downstream cellular responses.
• Academic & Institutional Research: A key reagent for universities and research institutes focusing on neurobiology, immunology, and cardiovascular physiology.
• Peptide Chemistry Studies: Used as a model compound for studying structure-activity relationships (SAR) and the effects of specific amino acid substitutions (D-amino acids, hydroxyproline) on peptide stability and function.

Basic Information

Product Name	(D-Arg0,Hyp2,3,D-Phe7)-Bradykinin
CAS No.	111929-26-1
Molecular Formula	C₅₆H₈₀N₁₆O₁₂
Molecular Weight	1153.4 g/mol
Synonyms	D-Arg0,Hyp3,Hyp3,D-Phe7-Bradykinin; [D-Arg0, Hyp3, Hyp3, D-Phe7]-Bradykinin; Bradykinin, D-Arg0,Hyp3,Hyp3,D-Phe7-; B9970; [Hyp3, Hyp3, D-Phe7]-Bradykinin (D-Arg0); Modified Bradykinin Analog; BK (1-9), D-Arg0,Hyp3,Hyp3,D-Phe7-
EINECS	Contact for details

Quality Control

Every batch of (D-Arg0,Hyp2,3,D-Phe7)-Bradykinin is produced and analyzed under strict quality management protocols. We ensure compliance with high-purity standards suitable for research and development applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and other critical parameters as verified by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.