Description

Dynorphin Amide (1-13), Ala(2)-(5-F-Phe)(4)- is a synthetic, fluorinated peptide analog of the endogenous opioid peptide dynorphin A (1-13). This modified compound is significant for its enhanced metabolic stability and binding affinity, making it a critical tool for advanced neuropharmacological research. It is primarily needed by research institutions and pharmaceutical R&D departments focused on opioid receptor studies, pain mechanism elucidation, and the development of novel neurotherapeutics.

Application

• Neuroscience Research: As a potent and selective κ-opioid receptor (KOR) ligand for studying receptor signaling, distribution, and function in the central nervous system.
• Pain Research: Investigation of dynorphin's role in pain pathways, neuropathic pain models, and the development of analgesic tolerance.
• Psychopharmacology Studies: Research into the effects of KOR activation on stress responses, mood disorders, addiction, and reward processing.
• Biochemical Assay Development: Used as a reference standard or labeled tracer in competitive binding assays (e.g., radioimmunoassays) and activity tests.
• Drug Discovery: Serving as a lead compound or pharmacophore model for the design of new peptide-based or small-molecule KOR-targeted therapeutics.
• Academic & Institutional Research: Fundamental research in universities and government labs exploring opioid peptide structure-activity relationships (SAR).

Basic Information

Product Name	Dynorphin Amide (1-13), Ala(2)-(5-F-Phe)(4)-
CAS No.	111846-43-6
Molecular Formula	C78H111FN20O18
Molecular Weight	1611.85 g/mol
Synonyms	[Ala2, p-F-Phe4]-Dynorphin A (1-13) amide; Dynorphin A (1-13) amide, [Ala2, 4'-F-Phe4]-; [Ala2, 4'-Fluoro-Phe4]-Dynorphin A (1-13)-NH2; Fluorinated Dynorphin (1-13) amide analog; p-Fluoro-Phe4-Dynorphin A (1-13) amide; Kappa opioid receptor peptide ligand; Tyr-Ala-Phe-p-fluoro-Phe-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-NH2
EINECS	Contact for details

Quality Control

Our Dynorphin Amide (1-13), Ala(2)-(5-F-Phe)(4)- is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for reproducible research outcomes. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Peptide Content)	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.