Description

Angiotensin II, Sar(1)-Phe(8)- is a potent and selective peptide analog of the endogenous vasoconstrictor hormone Angiotensin II. This compound is a critical research tool and a key intermediate in the development of cardiovascular therapeutics and diagnostic agents. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on the renin-angiotensin system (RAS), hypertension, and related metabolic disorders.

Application

• Biomedical Research: As a standard reference compound and selective ligand for studying Angiotensin II receptor (AT1) subtypes, signal transduction, and cellular responses.
• Drug Discovery & Development: Serving as a key pharmacophore and intermediate in the synthesis of novel receptor antagonists and agonists targeting cardiovascular diseases.
• In Vitro & Ex Vivo Assays: Used in receptor binding studies, functional assays (e.g., vascular contraction), and mechanistic studies to elucidate the pathophysiological role of the RAS.
• Biochemical Tool: Employed in the calibration of analytical instruments (HPLC, MS) and the validation of assay protocols for peptide quantification.
• Academic & Clinical Investigation: Facilitating fundamental research into hypertension, heart failure, renal function, and other disorders linked to the angiotensin pathway.

Basic Information

Product Name	Angiotensin II, Sar(1)-Phe(8)-
CAS No.	111821-46-6
Molecular Formula	C₄₉H₆₉N₁₃O₁₂
Molecular Weight	1032.2 g/mol
Synonyms	[Sar¹, Phe⁸]-Angiotensin II; Saralasin Acetate; Sarcosine¹, Isoleucine⁸-Angiotensin II; 1-Sar-8-Ile-Angiotensin II; (Sar-1,Ile-8)-Angiotensin II; Angiotensin II Antagonist (Saralasin); NSC 401005; UNII-4RZ82L2GY5
EINECS	Contact for details

Quality Control

Our Angiotensin II, Sar(1)-Phe(8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.