Description

Proline, 3,4-Dihydroxy-, (2Alpha,3Alpha,4Beta)- (9Ci) is a specialized, stereochemically defined derivative of the amino acid proline, featuring additional hydroxyl groups on its pyrrolidine ring. This unique structure makes it a valuable chiral building block and intermediate for advanced pharmaceutical synthesis and biochemical research. It is primarily sought by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutics and conducting structure-activity relationship studies.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly those targeting neurological and cardiovascular diseases.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and for probing the function of proline hydroxylases and related enzymes.
• Peptide Modification: Incorporated into synthetic peptides to study the effects of hydroxylation on peptide structure, stability, and biological activity.
• Asymmetric Catalysis: Serves as a precursor for developing novel chiral ligands and organocatalysts used in stereoselective chemical reactions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	Proline, 3,4-Dihydroxy-, (2Alpha,3Alpha,4Beta)- (9Ci)
CAS No.	111766-79-1
Molecular Formula	C5H9NO4
Molecular Weight	147.13 g/mol
Synonyms	(2S,3S,4R)-3,4-Dihydroxyproline; cis-3,4-Dihydroxy-L-proline; L-3,4-cis-Dihydroxyproline; (2α,3α,4β)-3,4-Dihydroxyproline; 3,4-DiOH-Pro; Hydroxyproline derivative
EINECS	Contact for details

Quality Control

Our Proline, 3,4-Dihydroxy-, (2Alpha,3Alpha,4Beta)- (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific analytical results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.