Description

Cyclosporin A, Meala(6)- CAS NO 111710-61-3 is a specific, high-purity derivative of the well-known immunosuppressive cyclic peptide, Cyclosporin A. This compound is of critical importance for advanced pharmaceutical research and development, particularly in the study of structure-activity relationships and the development of novel therapeutic agents. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on immunology, transplant medicine, and autoimmune disease research.

Application

• Pharmaceutical Reference Standard: Serves as a critical analytical standard for quality control and method development in the production of immunosuppressant drugs.
• Biochemical Research: Used as a key reagent in studying the mechanisms of T-cell activation, cytokine production, and calcineurin inhibition pathways.
• Drug Discovery & Development: Acts as a precursor or intermediate in the synthesis of novel Cyclosporin analogs with potentially improved efficacy or reduced side-effect profiles.
• Metabolism Studies: Employed in pharmacokinetic and metabolic stability research to understand the biotransformation of Cyclosporin derivatives.
• Cell Culture & In Vitro Assays: Utilized in immunology research to modulate immune responses in experimental cell-based systems.

Basic Information

Item	Details
Product Name	Cyclosporin A, Meala(6)-
CAS No.	111710-61-3
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	Cyclosporin A, MeBmt(6)-; [MeBmt6]-Cyclosporin A; Cyclosporin A, N-Methyl-L-leucine(6)-; (6-N-Methyl-L-leucine)cyclosporin A; MeLeu(6)-Cyclosporin A; Meala6-CsA; CsA derivative, Meala(6)
EINECS	Contact for details

Quality Control

Our Cyclosporin A, Meala(6)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and specific tests for related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.