Description

Cyclo(Lysyl-Prolyl) CAS NO 111688-85-8 is a synthetic cyclic dipeptide, also known as a diketopiperazine (DKP), formed from the amino acids L-lysine and L-proline. This compound is of significant interest in pharmaceutical research and development due to its role as a potential bioactive scaffold and a metabolite of larger peptide drugs. It serves as a critical intermediate and reference standard for researchers in medicinal chemistry, peptide synthesis, and analytical laboratories. The high-purity material is essential for ensuring the accuracy of pharmacokinetic studies and the quality control of related therapeutic peptides.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity profiling of related peptide-based active pharmaceutical ingredients (APIs) in compliance with pharmacopeial methods (e.g., USP, EP).
• Medicinal Chemistry Research: Serves as a core scaffold or building block for designing novel drug candidates, exploiting the bioactive properties of diketopiperazines.
• Metabolite Studies: Employed as an analytical standard in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the degradation pathways of parent peptide drugs.
• Biochemical Research: Utilized in studying enzyme inhibition, receptor binding, and other biological interactions due to its specific cyclic structure.
• Peptide Synthesis Intermediate: Acts as a protected dipeptide unit or a starting material for the synthesis of more complex peptide chains and conjugates.
• Quality Control & Assurance: Critical for the development and validation of analytical methods (HPLC, LC-MS) to ensure the purity and consistency of peptide products in GMP manufacturing.

Basic Information

Product Name	Cyclo(Lysyl-Prolyl)
CAS No.	111688-85-8
Molecular Formula	C11H19N3O2
Molecular Weight	225.29 g/mol
Synonyms	Cyclo(Lys-Pro); c(Lys-Pro); Lys-Pro Diketopiperazine; L-Lysyl-L-proline diketopiperazine; 3-(4-Aminobutyl)-6-(carboxymethyl)-2,5-piperazinedione; (3S,6S)-3-(4-Aminobutyl)-6-(carboxymethyl)piperazine-2,5-dione; DKP-Lys-Pro; Cyclo(L-lysyl-L-prolyl)
EINECS	Contact for details

Quality Control

Our Cyclo(Lysyl-Prolyl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and comprehensive identification tests. We provide full traceability and Certificates of Analysis (COA) detailing all specifications and test results. The product is suitable for use as a high-purity reference standard in pharmaceutical R&D and quality control environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.