Description

L-Ornithine, 2-Ethynyl- (9Ci) is a chemically modified derivative of the amino acid L-ornithine, featuring an ethynyl group at the 2-position. This structural modification makes it a valuable non-proteinogenic amino acid and a versatile building block in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and industrial R&D departments focused on developing novel bioactive compounds, enzyme inhibitors, and peptide mimetics. The compound's unique alkyne functionality provides a critical handle for click chemistry and other bio-conjugation strategies.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel drug candidates, particularly those targeting metabolic pathways or enzyme functions.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies to investigate the urea cycle and related amino acid metabolism.
• Peptide Chemistry: Acts as a modified amino acid residue for the synthesis of constrained or labeled peptides, enhancing stability or enabling tracking.
• Click Chemistry & Bioconjugation: The ethynyl group facilitates efficient Huisgen cycloaddition (copper-catalyzed azide-alkyne click chemistry) for labeling proteins, nucleic acids, or other biomolecules.
• Chemical Biology Probes: Integral for creating activity-based probes (ABPs) or photoaffinity labels to study protein function and interactions within biological systems.
• Academic & Industrial R&D: A critical tool for chemists and biologists in universities, CROs (Contract Research Organizations), and biotech companies exploring new chemical entities.

Basic Information

Item	Details
Product Name	L-Ornithine, 2-Ethynyl- (9Ci)
CAS No.	111656-45-2
Molecular Formula	C7H12N2O2
Molecular Weight	156.18 g/mol
Synonyms	2-Ethynyl-L-ornithine; (S)-2,5-Diamino-2-ethynylpentanoic acid; 2-Ethynylornithine; L-2-Ethynylornithine; (S)-2-Amino-5-amino-2-ethynylvaleric acid; 2-Ethynyl-DL-ornithine (related); NSC 339313 (related)
EINECS	Contact for details

Quality Control

Our L-Ornithine, 2-Ethynyl- (9Ci) is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify enantiomeric purity. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% (L-isomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.