Description

Ethyl 1-Acetyl-4-Methyl-6-(3-Nitrophenyl)-2-Oxo-1,2,3,6-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific therapeutic pathways. It is essential for research and development organizations and pharmaceutical manufacturers engaged in creating new drug candidates, especially within medicinal chemistry programs focused on central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules and novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities in drug discovery.
• Organic Synthesis Building Block: Used in academic and industrial laboratories for constructing complex dihydropyrimidine and tetrahydropyrimidine derivatives.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Biochemical Research: Potential utility in developing enzyme inhibitors or probes for biological studies due to its specific nitro-phenyl and acetyl functionalities.

Basic Information

Product Name	Ethyl 1-Acetyl-4-Methyl-6-(3-Nitrophenyl)-2-Oxo-1,2,3,6-Tetrahydropyrimidine-5-Carboxylate
CAS No.	111535-67-2
Molecular Formula	C₁₇H₁₇N₃O₆
Molecular Weight	359.34 g/mol
Synonyms	Ethyl 1-acetyl-4-methyl-6-(3-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxylate; 5-Carbethoxy-1-acetyl-4-methyl-6-(3-nitrophenyl)-1,2,3,6-tetrahydropyrimidin-2-one; 1,2,3,6-Tetrahydropyrimidine-5-carboxylic acid, 1-acetyl-4-methyl-6-(3-nitrophenyl)-2-oxo-, ethyl ester; 1-Acetyl-4-methyl-6-(3-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxylic acid ethyl ester; 6-(3-Nitrophenyl)-1-acetyl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxylic acid ethyl ester.
EINECS	Contact for details

Quality Control

Our Ethyl 1-Acetyl-4-Methyl-6-(3-Nitrophenyl)-2-Oxo-1,2,3,6-Tetrahydropyrimidine-5-Carboxylate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.