Description

Fmoc-D-Phg-Oh CAS NO 111524-95-9 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of the non-proteinogenic D-phenylglycine residue into peptide chains, enabling the creation of complex molecules with enhanced stability and biological activity. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-phase peptide synthesis (SPPS) for research and pharmaceutical development.
• Building block for the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Introduction of the D-phenylglycine residue to engineer peptides with improved metabolic stability and receptor selectivity.
• Production of custom peptides for biochemical and structure-activity relationship (SAR) studies.
• Key intermediate in the synthesis of complex peptidomimetics and constrained peptides.
• Tool compound for exploring protease resistance and altering peptide conformation.

Basic Information

Product Name	Fmoc-D-Phg-Oh
CAS No.	111524-95-9
Molecular Formula	C23H19NO4
Molecular Weight	373.40 g/mol
Synonyms	Fmoc-D-α-phenylglycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-α-phenylglycine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetic acid; Fmoc-D-Phenylglycine; Fmoc-D-Phg-OH; N-Fmoc-D-phenylglycine; D-2-(Fmoc-amino)-2-phenylacetic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-Phg-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98.5% (HPLC). Each lot undergoes comprehensive analytical testing including HPLC for purity, chiral HPLC to confirm enantiomeric excess, and NMR/IR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.