Description

Acth (1-39) (Guinea Pig) is a synthetic peptide fragment corresponding to the first 39 amino acids of the adrenocorticotropic hormone (ACTH), specifically derived from the guinea pig sequence. This high-purity biochemical is essential for research into the hypothalamic-pituitary-adrenal (HPA) axis, comparative endocrinology, and species-specific receptor binding studies. It is a critical reagent for pharmaceutical R&D, academic institutions, and biotechnology companies focused on developing and validating immunoassays, studying stress responses, and exploring novel therapeutic pathways.

Application

• Immunoassay Development & Validation: Used as a precise antigen standard for the development, calibration, and quality control of ELISA and RIA kits targeting guinea pig ACTH.
• Endocrine Research: Fundamental tool for in vitro and in vivo studies of the HPA axis function, corticosteroid release, and stress physiology in guinea pig models.
• Receptor Binding & Signaling Studies: Employed to investigate the interaction and activation kinetics of the melanocortin 2 receptor (MC2R) and related receptors in guinea pig tissues.
• Pharmaceutical R&D: Serves as a reference compound in the discovery and screening of drugs intended to modulate ACTH pathways or treat related disorders.
• Comparative Biology Studies: Enables research into the structural and functional differences of ACTH across species, aiding in evolutionary biology and translational medicine.
• Antibody Production: Acts as an immunogen for generating highly specific polyclonal or monoclonal antibodies against guinea pig ACTH.

Basic Information

Product Name	Acth (1-39) (Guinea Pig)
CAS No.	111524-36-8
Molecular Formula	C207H308N56O58S
Molecular Weight	4567.1 g/mol
Synonyms	ACTH (1-39), guinea pig; Adrenocorticotropic Hormone (1-39), guinea pig; Corticotropin (1-39); H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH (Guinea Pig); Guinea Pig ACTH; Synthetic ACTH Fragment (1-39); Melanocortin Receptor Ligand
EINECS	Contact for details

Quality Control

Our Acth (1-39) (Guinea Pig) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.