Description

Pancreastatin-52 CAS NO 111364-77-3 is a bioactive peptide fragment derived from the chromogranin A protein, known for its role in regulating pancreatic endocrine secretion. This high-purity compound is critical for advanced biochemical research and pharmaceutical development, particularly in studies of metabolic disorders and hormone regulation. It is an essential reagent for researchers and manufacturers in the fields of endocrinology, peptide therapeutics, and diagnostic assay development.

Application

• Biochemical Research: Used as a reference standard and active agent in studies investigating pancreatic hormone secretion, insulin regulation, and glucose homeostasis.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of novel peptide-based therapeutics targeting metabolic diseases.
• Diagnostic Assays: Employed as a critical component in the development and calibration of immunoassays (ELISA, RIA) for measuring chromogranin A and related peptides in clinical samples.
• Cell Biology Studies: Applied in in vitro cell culture models to study the paracrine and autocrine signaling mechanisms of chromogranin A-derived peptides.
• Neuroscience Research: Utilized in neuroendocrine research to explore the gut-brain-pancreas axis and the role of pancreastatin in appetite and energy balance.

Basic Information

Product Name	Pancreastatin-52
CAS No.	111364-77-3
Molecular Formula	C254H402N72O73S2
Molecular Weight	~5730.6 g/mol
Synonyms	Human Pancreastatin (1-52); PST-52; Chromogranin A (250-301); hPST (1-52); CgA (250-301); Pancreastatin Fragment (1-52); Chromogranin A-derived Pancreastatin; Chromogranin A Peptide (250-301)
EINECS	Contact for details

Quality Control

Every batch of Pancreastatin-52 is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, MS, and amino acid analysis, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and impurity profiles is provided with each shipment. We support research and GMP-grade requirements, with specifications tailored to your application.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under desiccant or in a nitrogen atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Conforms to theoretical values (±10%)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.