Description

n-Acetylmuramyl-Alanyl-Isoglutaminyl-(3'-Iodo-4'-Azidophenylalanine) Methyl Ester is a specialized synthetic peptide derivative designed for advanced biochemical research and development. This compound is a critical tool for studying and modulating immune system responses, particularly through its interaction with NOD2 (Nucleotide-binding oligomerization domain-containing protein 2) receptors. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on immunology, inflammation, and novel therapeutic discovery.

Application

• Immunological Research: As a potent and specific ligand for the NOD2 receptor, it is used to study innate immune signaling pathways, inflammasome activation, and cytokine production.
• Drug Discovery & Screening: Serves as a key reference standard and active probe in high-throughput screening (HTS) assays to identify novel anti-inflammatory compounds or NOD2 pathway modulators.
• Bioconjugation & Probe Development: The presence of the 3'-Iodo-4'-Azidophenylalanine moiety allows for site-specific photoaffinity labeling and "click chemistry" applications, enabling the study of protein-peptide interactions.
• Vaccine Adjuvant Research: Investigated for its potential as a synthetic derivative of muramyl dipeptide (MDP) to enhance and modulate vaccine immune responses.
• Inflammatory Disease Models: Used in cellular and animal models to induce controlled inflammatory responses for studying conditions like Crohn's disease, arthritis, and other autoinflammatory disorders.
• Biochemical Tool Compound: Provides a precise chemical tool for elucidating the structure-activity relationship (SAR) of NOD2 agonists and antagonists.

Basic Information

Product Name	n-Acetylmuramyl-Alanyl-Isoglutaminyl-(3'-Iodo-4'-Azidophenylalanine) Methyl Ester
CAS No.	111364-35-3
Molecular Formula	C31H44IN7O12
Molecular Weight	857.62 g/mol
Synonyms	MDP-Iodo-Azido-Phe-OMe; N-Acetylmuramyl-L-alanyl-D-isoglutaminyl-(3'-iodo-4'-azido-L-phenylalanine) Methyl Ester; L18-MDP (Iodo-Azido Derivative); NOD2 Agonist Probe; Muramyl Dipeptide Iodoazidophenylalanine Derivative; Photoaffinity Labeled MDP; CAS 111364-35-3
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical is governed by strict quality management protocols. Each batch is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity, purity, and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment ensures material suitable for sensitive research applications, with purity typically exceeding 95% (by HPLC).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.