Description

2-(4-Chloromethyl-Piperidin-1-Yl)-Pyrimidine is a versatile and high-value pharmaceutical intermediate with the CAS number 111247-62-2. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring piperidine and pyrimidine scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic structure for biological activity.
• Chemical Synthesis: Serves as a versatile precursor in organic chemistry for constructing complex nitrogen-containing heterocycles.
• Bioconjugation & Probe Development: Utilized in medicinal chemistry for creating labeled compounds and molecular probes for biochemical assays.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for custom synthesis and scale-up projects under cGMP guidelines.

Basic Information

Product Name	2-(4-Chloromethyl-Piperidin-1-Yl)-Pyrimidine
CAS No.	111247-62-2
Molecular Formula	C10H14ClN3
Molecular Weight	211.69 g/mol
Synonyms	1-(Pyrimidin-2-yl)-4-(chloromethyl)piperidine; 4-(Chloromethyl)-1-(2-pyrimidinyl)piperidine; 2-(4-Chloromethyl-1-piperidinyl)pyrimidine; 2-(4-Chloromethylpiperidin-1-yl)pyrimidine; 111247-62-2; 4-(Chloromethyl)-1-pyrimidin-2-ylpiperidine
EINECS	Contact for details

Quality Control

Our 2-(4-Chloromethyl-Piperidin-1-Yl)-Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.