Description

4-Chloro-5-Iodo-2-Methylthiopyrimidine is a high-purity halogenated pyrimidine derivative, a key heterocyclic building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides multiple reactive sites for selective functionalization, making it indispensable for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other targeted therapeutic agents.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators due to its bioactive pyrimidine core.
• Chemical Biology Probe: Acts as a versatile scaffold for creating molecular probes to study enzyme mechanisms and biological pathways.
• Material Science: Employed in the research and development of organic electronic materials and liquid crystals.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleic Acid Chemistry: Utilized in the modification of nucleosides and oligonucleotides for medicinal and diagnostic applications.

Basic Information

Product Name	4-Chloro-5-Iodo-2-Methylthiopyrimidine
CAS No.	111079-19-7
Molecular Formula	C5H4ClIN2S
Molecular Weight	286.52 g/mol
Synonyms	2-(Methylthio)-4-chloro-5-iodopyrimidine; 4-Chloro-5-iodo-2-(methylthio)pyrimidine; 4-Chloro-5-iodo-2-methylsulfanylpyrimidine; 5-Iodo-4-chloro-2-methylthiopyrimidine; 4-Chloro-5-iodo-2-(methylmercapto)pyrimidine; 2-Methylthio-4-chloro-5-iodopyrimidine; Pyrimidine, 4-chloro-5-iodo-2-(methylthio)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Iodo-2-Methylthiopyrimidine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.