Description

8-Bromo-7-(2,3-Dihydroxypropyl)-1,3-Dimethyl-2,3,6,7-Tetrahydro-1H-2,6-Purinedione is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel therapeutic agents, particularly xanthine derivatives and adenosine receptor modulators. It is essential for research and development laboratories and production facilities in the pharmaceutical and fine chemical industries seeking reliable, high-quality raw materials for complex organic synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel xanthine-based pharmaceuticals and bioactive molecules.
• Adenosine Receptor Research: Used in the development and study of ligands for adenosine A1, A2A, A2B, and A3 receptors due to its modified purine core.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Research: Employed as a tool compound to investigate purinergic signaling pathways and related physiological processes.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for creating complex, high-value specialty chemicals.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.

Basic Information

Item	Detail
Product Name	8-Bromo-7-(2,3-Dihydroxypropyl)-1,3-Dimethyl-2,3,6,7-Tetrahydro-1H-2,6-Purinedione
CAS No.	111038-24-5
Molecular Formula	C₁₀H₁₅BrN₄O₄
Molecular Weight	335.16 g/mol
Synonyms	8-Bromo-7-(2,3-dihydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione; 8-Bromo-7-(2,3-dihydroxypropyl)theophylline; 8-Bromotheophylline derivative; 1,3-Dimethyl-8-bromo-7-(2,3-dihydroxypropyl)xanthine; 8-Bromo-7-(2,3-dihydroxypropyl)-1,3-dimethylxanthine; 8-Bromo-7-(2,3-dihydroxypropyl)paraxanthine; 8-Bromo-PD 116,948 (related analog); Brominated xanthine derivative
EINECS	Contact for details

Quality Control

Our 8-Bromo-7-(2,3-Dihydroxypropyl)-1,3-Dimethyl-2,3,6,7-Tetrahydro-1H-2,6-Purinedione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.